Do oxidized lipoproteins contribute to glomerulosclerosis?

Oxidized Low Density Lipoproteins

The direct vasoactive effects of native and oxidatively modified low density lipoproteins as well as their effects on endothelium-dependent relaxations to 5-hydroxytryptamine were studied in isolated rings of pig right coronary artery. Slowly developing contractions were caused by native low density lipoproteins (100 gg protein/ml). The contractions were more pronounced in the absence than in t...

How international visitors do contribute to management processes of Perhentian Island Marine Park Malaysia?

Oxidized HDL: the paradox-idation of lipoproteins.

The strong inverse relationship between HDL level and risk for coronary artery disease has been attributed to different mechanisms. More than 30 years ago, Glomset1 proposed that HDL mediates the transfer of cholesterol from peripheral tissues to the liver, where the sterol and its oxygenated products are excreted into the bile. Subsequent studies demonstrated that HDL accepts cholesterol from ...

What do muscles have to do with lipoproteins?

We ell-trained endurance athletes have average high density lipoprotein cholesterol (HDL-C) concentrations 20 mg/dl or 4050% higher than those of sedentary men.1-3 Triglyceride levels characteristically are 20% lower in these athletes, and low density lipoprotein cholesterol (LDLC) may be 5-10% less.12 Since skeletal muscles neither secrete nor directly catabolize lipoproteins, what links muscu...

Oxidized low-density lipoprotein in experimental focal glomerulosclerosis.

Oxidized low-density lipoproteins (Ox-LDL) have been shown to be involved in the pathogenesis of atherosclerosis. Because of the similarities between atherosclerosis and focal glomerulosclerosis, a study was performed to demonstrate whether Ox-LDL could be detected in the glomeruli in experimental FGS. FGS was induced in 12 rats on a 4% cholesterol-1% choline diet by seven injections of puromyc...